In order to advance medical research in these important areas, it has been important to operate in an environment that accurately represents the BBB. As such, researchers have turned to animal subjects, something which comes with significant ethical and moral questions. The desire has been, therefore, to create some type of substitute for a living creature, but limits to current fabrication techniques had made such models impossible to produce. That is, until now. In an article recently published in the journal Small researchers detailed a breakthrough in high resolution 3D printing that has allowed them to “faithfully reproduc[e] the microcapillaries of the neurovascular system on a 1:1 scale.” As explained by Gianni Ciofani, Associate Professor at Polytechnic University of Torino and Principal Investigator of the Smart Bio-Interfaces group at the Italian Institute of Technology:
“The bio-hybrid BBB developed in our laboratories allows [one] to carry out high-throughput screening of different drugs/compounds/nanovectors, and to evaluate their ability to cross the BBB. Furthermore, our bio-hybrid platform allows [one] to rigorously study the BBB crossing by avoiding the use of animal models, thus overcoming the issues related to the scarce accessibility of the brain and limiting important ethical concerns.”

Confocal acquisition of the bio-hybrid BBB model (f-actin, ZO-1 and nuclei of bEnd3 cells have been stained in red, green and blue respectively). [Image: Gianni Ciofani, IIT]
“The novelty of our work mainly consists in the fabrication of a reliable platform to carry out high throughput quantitative investigations of drug delivery to the brain. The in vitro model provides a closed system where the different variables such as drug concentration, blood flow speed, pH, and temperature can be easily turned and monitored, thus providing precious and detailed information about the BBB crossing in real time and at cellular/subcellular levels.”

3D rendering of confocal acquisition of the bio-hybrid BBB model (f-actin, ZO-1 and nuclei of bEnd3 cells have been stained in red, green and blue respectively). [Image: Gianni Ciofani, IIT]
“We strongly believe that nanotechnology-based solutions such as nanocarriers and nanovectors for thernostic applications show enormous potential for the treatment of brain pathologies…In this context, the new generation of remotely triggered smart nanomaterials represents, in our opinion, the future solution for the treatment of brain diseases. The BBB model we developed represents a powerful testing tool to achieve these goals.”
What do you think of this news? Let us know your thoughts; join the discussion of this and other 3D printing topics at 3DPrintBoard.com or share your thoughts below.
[Source: Nanowerk]
Subscribe to Our Email Newsletter
Stay up-to-date on all the latest news from the 3D printing industry and receive information and offers from third party vendors.
You May Also Like
Deutsche Bahn Certifies Essentium’s 3D Printing Platform for Rail Parts
Essentium, the Austin-based original equipment manufacturer (OEM) of additive manufacturing (AM) platforms, announced that its High Speed Extrusion (HSE) printer has been certified for use by Deutsche Bahn (DB), Germany’s...
Toyota Taps SOLIZE to 3D Print Functional Parts for Lexus
Recently, Japanese reseller and 3D printing service SOLIZE has achieved notable success. In 2021, the company began manufacturing 3D printed components for Nissan’s NISMO brand, utilizing HP printers. Now, SOLIZE...
3D Printing News Briefs, September 2, 2023: Alloy Testing, Modular Buildings, & More
Today’s 3D Printing News Briefs run the gamut from defense 3D printing and research to 3D printed modular buildings and more. Read on for all of the details! AML3D Receives...
3D Printing News Briefs, August 26, 2023: Materials, Electroplating, Consumer Goods, & More
It’s all materials, all the time in today’s 3D Printing News Briefs, starting with AddUp adding an aluminum alloy by Constellium to its materials portfolio. igus introduced an online service...