In ‘Mechanical properties and in vitro degradation behavior of additively manufactured phosphate glass particles/fibers reinforced polyactide,’ authors Lizhe He, Jiahui Zhong, Chenkai Zhu, and Xiaoling Liu explore a new level of material for 3D printing with phosphate glass/polylactide (PG/PLA) composites for use in medical applications such as fabrication of customized bone fixation plates for repairing fractures.
While bone regeneration is an area of great interest in 3D printing and additive manufacturing, so is the more common element of healing breaks, as researchers continue to look for better ways to improve the process—often accompanied by a range of bone fixation plates, screws, pins, and rods. Materials are key, along with integrity in design. Implants must be biocompatible, but the process is seamless when they are biodegradable too, thus eliminating the need for surgery.
The materials were tested for suitable mechanical properties as well as in vitro degradation behavior after creating models designed with PTC Creo Parametric, which were then imported into Simplify3D and the PG/PLA composites were 3D printed on an Ultimaker 2+. With the ability to fabricate complex geometries, the researchers could also control the level of porosity for bioprinting and tissue engineering purposes.
“Comparisons were made with PLA, and PLA reinforced with different loadings of PG particles (PGPs) as well as composites with reinforcements of different geometries [PGPs or milled phosphate glass fibers (PGFs)].”
The aim was to evaluate the AM composites as fracture fixation plates. A three-point bending test was performed, along with in vitro degradation for examining the strength and hydroscopy of the composites. There was a pH value check, along with dynamic mechanical analysis, and fiber length and laser particle size analysis. Both microscopy and statistical analysis were performed also.
In continuing to compare with PLA specimens, the authors noted the following:
- Improved flexural modulus
- Reduced flexural strength
- Reduced strain at break
- Intensified effects with increased PGP loading
“Embrittlement and strength reduction are associated with of stress concentration and low interfacial strength. It is likely here that the stress concentration effect was augmented by the incorporation of particulate with sharp corners. With increased filler loading, stress concentration sites also increased and led to more pronounced strength reduction and the same effect on strain at failure,” noted the authors.
Here, the average fiber length was 54 μm, and median and mode of fiber length were even lower. In comparison to authentic cortical bones, the PGF 10 composite was noted by the researchers to be ‘a close approximation,’ although flexural modulus was found to be considerably lower.
“Stiffness matching is recognized as the ‘gold standard’ for bone fixation implants, as fixation implants with such mechanical properties are strong and stiff enough for the load‐bearing activities without leading to ‘stress shielding.’ As such, it is probably necessary to consider the use of higher/longer fiber loading for this type of application,” stated the researchers.
Continuous PGF/PLA composites are more ‘suitable,’ according to the authors, in regard to load-bearing fixation—a feature connected with continuous fibers leading to stiffness. The flexural modulus of these materials, however, was reduced by ~80% after 28 days of degradation. The PGF 10 composites lost ~30% of initial flexural modulus after a degradation period of 56 days. The rapid flexural modulus could have been a result of the fiber ends being exposed in degradation media.
“Based on the consideration of both the initial mechanical properties and the facility to produce composites with desired geometries straightforwardly, the additive manufacturing of PG/PLA composites exhibits good potential in the making of patient‐specific fixation implants for bone that has low demand for load‐bearing, for example, zygoma, ankle, and maxilla,” concluded the researchers.
“These bones have been previously reported to be successfully restored using PLA‐based biodegradable fixation devices. Compared to PLA alone, it was demonstrated that the incorporation of PGF enhanced the flexural modulus of implants. It is also anticipated that the degradation of PGF releases magnesium, calcium, and phosphate to upregulate bone regrowth. Moreover, the FDM process allows fixation implants with customized geometries to be built directly and may remove the need for contouring of implants for anatomic fit during the operation.”
A serious interest in 3D printing today translates into a serious interest in materials—and most likely composites too, as they are able to add significant strength and improved properties to prototypes and parts, including that of polymers, bioprinting applications, and metals like titanium. What do you think of this news? Let us know your thoughts! Join the discussion of this and other 3D printing topics at 3DPrintBoard.com.[Source / Images: ‘Mechanical properties and in vitro degradation behavior of additively manufactured phosphate glass particles/fibers reinforced polyactide‘]
Subscribe to Our Email Newsletter
Stay up-to-date on all the latest news from the 3D printing industry and receive information and offers from third party vendors.
You May Also Like
CELLINK Bioprinter Enables Bioprinted Hair Follicles for Skin Regeneration and More
In a landmark achievement, researchers at Rensselaer Polytechnic Institute in New York have successfully 3D-printed hair follicles in lab-grown human skin tissue, marking a significant advancement in the field of...
BICO’s Revival: A Fresh Era with Maria Forss at the Helm
Swedish biotech company BICO (STO: BICO) has been making waves in the industry recently. Ever since Maria Forss assumed the role of CEO in November 2023, the company seems to...
3D Printing Webinar and Event Roundup: November 26, 2023
Things are getting busy again in terms of 3D printing webinars and events! This week is the RSNA annual meeting, the World Manufacturing Forum, and more. HP is holding an...
3D Printing Webinar and Event Roundup: November 5, 2023
Happy Formnext week! But don’t worry, if you can’t make it to Germany this week, there are still several other in-person and online webinar and event options in the industry....
Upload your 3D Models and get them printed quickly and efficiently.