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A Bioprinting World Map

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With 119 established bioprinting companies and many entrepreneurs worldwide showing interest in the emerging field, it’s just a matter of time before it becomes one of the most sought-after technologies. Mapping the companies that make up this industry is a good starting point to understand the bioprinting ecosystem, determine where most companies have established their headquarters, and learn more about potential hubs, like the one in San Francisco. The technology has gained increasing attention due to the ability to control the placement of cells, biomaterials, and molecules for tissue regeneration. For example, researchers are using bioprinting to create cardiac patches meant to be transplanted directly onto a patient’s heart after a cardiovascular attack, as well as custom printing an implant to precisely fill the space left after removing diseased bone. In addition, bioprinting has been used to test for 3D printing of tailored skin grafts for patients with large wound areas, print muscle, and even for micro stereolithography 3D printing to repair damaged nerve connections. Bioprinting companies worldwide are continuously innovating in regenerative medicine, drug therapies, tissue engineering, stem cell biology, and biotechnology, getting a lot of attention from a public eager to envision a future with better patient care, alternatives to organ transplants, and customized medical treatments. To increase knowledge and research, most bioprinting firms have established partnerships with several research organizations, universities, and even government institutions, to jointly create and develop projects that are often published in academic journals. Actually, the literature available on the subject to date is quite vast and growing thanks to the advances in biotechnology and is a great tool for communicating and validating most of this breakthrough knowledge.

The data we collected reveals that the United States is the biggest player, with 39 percent of the companies headquartered in 18 states. And although 28% of the total number of companies in the US are located in California, 33 percent have emerged in East Coast states like Massachusetts, New York, New Jersey, and Maryland. The European continent is home to 35 percent of the companies, followed by Asia with 17 percent, Latin America (5%), and Oceania (3%). Countries like Great Britain, Germany, and France absorb most of the businesses, representing a 53% stake out of all the European companies. The leader in Asia is China, with three big names. However, the country is heavily relying on university research to advance the technology, and researchers are using their own in-house designed research, which is probably why we are still waiting to see an expansion of companies.  

Researchers, private companies, and universities everywhere are very interested in advancing bioprinting technologies. And although there is a long way to determine how these results will perform in a clinical setting, advances show that the potential in therapeutic and regenerative medicine, surgeries, and overall healthcare is huge. Even 4D bioprinting may have the potential for greater strides in medicine and tissue regeneration since it shows more control over pore size, shape, and interconnectivity. In addition, the bioprinting business gives scientists and medical researchers the tools to prototype, model, build, and solidify living human tissues. From printing machines to bioinks, even scanners and software to further enhance their work, this interconnected environment has the potential to transform life as we know it.

Pioneer companies such as Organovo, regenHUCELLINK, and Digilab have been at the forefront of bioprinting for years, creating some of the most innovative machines in the market, which in the right hands, can make all the difference—such as the case with Organovo’s bioprinting platform, recently implemented by Leiden University Medical Center scientists to develop stem cell-based bioprinted tissue treatments for kidney disease, or Cellink’s Bio X machine, which a Florida A&M University professor used to create the first 3D print of human cornea in the United States.

Many of these businesses focus on tissue engineerings, like Cyfuse Biomedical, Regenovo Biotechnology, Aspect Biosystems, or nScrypt. For instance, researchers using Allevi printers have been automating the creation of tumor models, printing vasculature within 3D gels, and achieving physiological markers unseen before in tissues. This requires a ton of knowledge about the microenvironment of the specific tissues and organs through biomimicry or by manufacturing artificial tissues or organs by reproducing cellular and extracellular components natively present. This know-how is essential for in vitro manufacturing living tissues with the same size and geometry as native organs.

Many commercially available 3D bioprinters are used in several research areas, like bioengineering, disease modeling, or studies of biomaterials. There are different versions, including syringe-based extrusion of hydrogels or bioinks, inkjet printing, laser-induced forward transfer (LIFT) (which is a relatively new printing technique that enables transfer from a thin-film donor material onto a chosen receiver placed nearby), and stereolithography (a form of 3D printing technology used for creating models, prototypes, patterns, and production parts in a layer by layer fashion using photopolymerization).

Bioprinting is leading the way into some of the most advanced research ever done in medicine, becoming a beaming source of hope for hundreds of thousands of people who consider the future of healthcare to be focused on patient-specific treatment and increased life expectancies. Thanks to many of the breakthroughs done at research facilities around the globe and booming interest in the technology applications, perhaps in a year, our map will need to be updated, and bioprinting companies will have increased significantly. Still, the core of what they are doing has remained the same for the past couple of years. In addition, partnerships continue to emerge among businesses, scientists, and researchers, eager to apply their innovative spirit, knowledge of biological sciences, engineering, mathematics, and other fields that are contributing to the unstoppable evolution of bioprinting, so that it can eventually transition from the research and development phases to the pre-clinical and trial, getting one step closer to changing people’s lives.

NORTH AMERICA

The US and Canadian bioprinting market include the following companies:

  1. 3D BioTherapeutics
  2. 3D Biotek
  3. 3D Cultures
  4. Advanced BioMatrix (acquired by BICO)
  5. Advanced Solutions Life Sciences
  6. Aether Bio
  7. Allegro 3D (acquired by BICO)
  8. Allevi (acquired by 3D Systems)
  9. Aspect Biosystems
  10. BICO (formerly Cellink)
  11. BioLife 4D
  12. Biomomentum
  13. Biospherix
  14. Cell Applications
  15. Cellular Life Sciences (formerly DigiLab)
  16. Celprogen
  17. Chemo Sen (formerly Nano 3D Biosciences)
  18. Dimension Inx
  19. Embodi3D (closed)
  20. EnvisionTEC (acquired by Desktop Metal)
  21. Fluidform
  22. Frontier Bio
  23. Humabiologics
  24. Hyrel
  25. International Stem Cell
  26. Koligo Therapeutics (acquired by Orgenesis)
  27. Lung Biotechnology PBC (United Therapeutics subsidiary)
  28. MicroFab Technologies
  29. ChemoSen3D (formerly Nano 3D Biosciences)
  30. Nanofiber Solutions
  31. nScrypt
  32. OrganoFab Technologies
  33. Organovo
  34. PreciseBio
  35. Prellis Biologics
  36. Qrons
  37. Rainbow Bioscience (closed)
  38. Ronawk
  39. Rooster Bio
  40. Samsara Sciences (Organovo subsidiary)
  41. SE3D
  42. SunP Biotech
  43. TeVido Biodevices
  44. TheWell Bioscience
  45. Tissue Regeneration Systems (acquired by Johnson & Johnson‘s DePuy Synthes)
  46. United Therapeutics Corporation
  47. Viscient Biosciences
  48. Vivax Bio
  49. Volumetric (acquired by 3D Systems)
  50. VoxCell BioInnovation

EUROPE

The European bioprinting ecosystem is as follows:

  1. 3D Bioprinting Solutions
  2. 3Dynamic Systems (closed)
  3. ArrayJet
  4. Artificial Nature
  5. Auregen BioTherapeutics
  6. Axolotl Biosystems
  7. BiogelX
  8. Biolamina
  9. Black Drop Biodrucker
  10. Brinter
  11. Cellbricks
  12. Cellenion (acquired by BICO)
  13. CELLnTEC
  14. Clexbio
  15. CTI Biotech
  16. Ebers
  17. FabRx
  18. Fluicell
  19. GeSim
  20. Greiner Bio-One
  21. Healshape
  22. I&L Biosystems SAS
  23. Innotere
  24. Innov’Gel (closed)
  25. Jellagen
  26. Labnatek (acquired by Sygnis Bio Technologies)
  27. Manchester BIOGEL
  28. Medprin Biotech
  29. mimiX biotherapeutics
  30. Morphodyne (closed)
  31. Nuclera
  32. Ourobionics
  33. Ourobotics (closed)
  34. Oxford MEStar
  35. OxSyBio (closed)
  36. PhosPrint
  37. Poietis
  38. Printivo
  39. ProColl
  40. Regemat 3D
  41. regenHu
  42. Renovo
  43. Censo Biotechnologies (acquired by Axol Bioscience)
  44. Sygnis Bio Technologies
  45. Vornia Biomaterials (closed)

ASIA

Asia’s new and booming bioprinting market:

  1. 3DPL (moved to Canada)
  2. Accellta
  3. BioP India
  4. CLECELL
  5. CollPlant
  6. Cyfuse Biomedical
  7. FoldInk Bioprinting
  8. IndiBio
  9. KosmodeHealth
  10. Matricelf
  11. MedPrin
  12. Next Big Innovation Labs
  13. OmidAfarinan 3D-Bio
  14. OrgaNow
  15. Osteopore
  16. Pandorum technologies
  17. PepPrint
  18. Regenovo
  19. Revotek
  20. Rokit Healthcare

OCEANIA

Oceania’s bioprinting ecosystem:

  1. Inventia Life Sciences
  2. MyoFab (closed)
  3. Sonic Regen (closed)

LATIN AMERICA

Latin America’s incipient bioprinting environment:

  1. 3D Biotechnology Solutions
  2. BioEdTech
  3. BioPrint 3D
  4. Life SI
  5. WeBio (closed)
  6. Tissue Labs (moved to Switzerland)

Is your company not listed? Email michael@3DPrint.com or vanesa@3DPrint.com

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