Lowering the Barrier to Entry for 3D Bioprinting – AMS Speaker Spotlight

3D bioprinting presents great potential as a versatile technology that is transforming animal-free research models. The success it has demonstrated in effectively recapitulating human biological systems prompted pioneers in the biomedical industry to be early adopters of the technology. As the platform expands its reach into drug discovery, regenerative medicine, translational medicine, and preclinical therapeutics research, the promises of 3D bioprinting speaks for itself.

With the most recent update on the FDA Modernization Act, which removes the requirement for animal testing before drugs reach the market, we are seeing more efforts in developing animal-free preclinical models and systems. The many challenges in preclinical research are identifying relevant human models and samples to demonstrate statistically significant data; 3D bioprinted models and organs-on-chips present innovative solutions to bridge the gap and accelerate advances in human-based in vitro models. These technologies enable the creation of physiologically relevant 3D constructs composed of human cells and tissue-based materials that recapitulate human organ, tissue, and disease structure and function.

Preclinical research could benefit from 3D bioprinting solutions to develop animal-free models

But where do we start? Many customers doing biomedical research have expressed the desire to adopt 3D bioprinting into their project pipelines but simply do not know where to start. As a trained scientist, my many years of experience working at the bench in immunology labs have included developing animal models and spending countless hours in the animal and flow cytometer rooms. In a world where your everyday tasks are divided into protocols and assays, it is easy to get stuck in a rut, in the tried and tested lab-established protocol that got your Principal Investigator (PI) their first Nature publication that since then has been passed down postdoc to postdoc.

To move the needle, we need more than hand-me-down projects, and while many scientists have approached us expressing their interest in bioprinting, the barrier to entry remains high for such a community. What Allevi has learned is that the bioprinting business is not just commercializing bioprinters, it involves an entire ecosystem around bioprinting technology, comprising bioprinters, bioinks and biomaterials, bioprinting services, and customized solutions. This streamlined bioprinting solution offers full-service support for novices to the technology and allows our current customers to quickly adopt and integrate the system into their research protocols.

3D cell culture better represents in vivo human physiology

It is not lost on researchers that the time, money, and effort spent on animal models and collecting quality human samples that yielded good data could be invested in learning novel systems that set their research apart from the mainstream labs. The true value 3D bioprinting brings is a highly sustainable and adaptable technique and technology that once familiarized sets researchers up for long-term success. However, to develop a repertoire of 3D bioprinting protocols that spans different disease models, organs, cell types, and biomaterials, scientists will need a team of materials scientists and biomedical engineers to design, troubleshoot and optimize said protocols. The toolbox does not expand itself by simply having a bioprinter in the lab. This is a journey that requires a partner for success along the way. The research labs that have figured out how to blend their curiosity with the expertise of an external partner are not only maximizing their investment in the bioprinter, they are able to develop unique models that are enabling breakthroughs in their field.

3D Systems is participating at Additive Manufacturing Strategies, taking place in New York City from February 7-9, 2023. Dr. Hanchih (Han) Wu, Commercial Director of Bioprinting at Allevi, a 3D Systems company, will be taking part in Session 1, Panel 1: Bioprinting: New Technology and Commercialization on February 7. Register for your ticket to attend here.