Taking a drug to market is a competitive, costly and challenging process involving preclinical laboratory and animal testing before the even more time-consuming and expensive four phases of human clinical trials, which can take as many as 7 to 15 years at price tags as high as $5.5 billion. Even if 10 viable drug compounds are identified for human trials, only 1 out of 9 will actually make it to market. Given this high attrition rate, can bioprinting save valuable time and resources by better identifying viable compounds in order to move only the most promising drugs to clinical trials?
The limitations of animal testing
During the initial stages of drug discovery, often referred to as preclinical trials, new chemical entities (NCEs) are monitored to determine the life cycle of the compounds inside and outside of the targeted system (pharmacokinetics) and their chemical reactions (metabolism). Because of the ethical issues surrounding human trials and their high costs, a significant number of these early tests are performed on animals.
While the transition from preclinical animal testing to clinical human trials has improved thanks to better research tools and the rise of artificial intelligence in target identification, there is still a real need for improved preclinical screening because animal testing often fails to recapitulate the complexity of the human metabolism, leading to false positives and negatives that do not accurately reflect the toxicity of drugs to human systems.
3D cell cultures are more relevant
Given the limitations of animal models, it is no wonder that scientists have turned to human organ models. But although human cells have long been cultured in 2D, in recent years, a paradigm shift has led more and more scientists to recognize the importance of working with human cells in the 3D environments afforded by bioprinting in order to produce more physiologically relevant models. Combining the automation of cell culturing in 3D bioprinting with carefully tailored biomaterials, known as bioinks, has made it possible to grow, feed and maintain human organ models in larger quantities and in a lot less time, reducing time and labor spent on these tasks. Laboratory robotics can also now pick and place cell culture reagents or other NCEs and liquid samples in high numbers, enabling higher throughput screening and running a variety of other laboratory tasks more efficiently.
Bioinks better mimic ECM
Bioinks are another powerful tool that help researchers advance their drug discovery research. Tissue-specific bioinks improve cell adhesion and differentiation, helping with the formation of human organoids. Proteins and other biological factors can also be added to more accurately recreate extracellular matrices (ECM), once again better simulating the in vivo microenvironments. Furthermore, with multiple methods of crosslinking (chemical, light, thermal), the stiffness of constructs can be modulated to better serve specific cell types, like cartilage or bone tissue.
Bioprinting’s more relevant human organ models can save the drug industry time and money by more efficiently identifying viable compounds in the initial stages of drug development in order to move only the most promising compounds to costly human clinical trials. The technology’s growing influence means that scientists continue to validate more and more applications. Dive deeper into how the bioprinting industry is changing drug screening and development. Watch our webinar on 3D bioprinting for COVID-19 studies or read our application note, which discusses the effectiveness of testing drug efficacy in 2D and 3D.
You May Also Like
Argonne National Lab Tests Weather Stations with Low-Cost Sensors and 3D Printed Components
For two years right out of college, I worked as an associate producer at a local CBS affiliate, and spent a lot of time learning the ins and outs of...
LLNL Researchers Bioprint Living Aneurysm and Watch it Heal Post-Op
Cerebral aneurysms, caused by the artery walls in the brain weakening, affect roughly one in every 50 people in the US, and are distinguished by a bulging blood vessel, which...
I-nteract Allows User to Design, Feel and 3D Print Objects in Mixed Reality
Due to their general ubiquity, it may not be readily apparent just how unintuitive computers are for the process of 3D computer aided design (CAD). A mouse or trackpad along...
Smallest 3D Printed Boat Yields Possibilities for Nanotechnology
We’ve seen some big 3D printed Benchy boats before, but I bet you’ve never seen one this small! A team of researchers from Leiden University in the Netherlands have published...
View our broad assortment of in house and third party products.