In the recently published ‘Shape-programmed 3D printed swimming microtori for the transport of passive and active agents,’ international researchers explore the challenges in mimicking the ‘unique swimming behaviors’ of microorganisms—for the purposes of microfabrication. With 3D printing on the nanoscale, however, they have been able to design microscopic tori for transporting biological matter.
Active matter systems are becoming more interesting to researchers as a topic of study, but to be functional they must be able to adapt to their environment, must be capable of complex behavior, and able to function as self-propelled swimmers.
“Bacterial systems show a wide variety of complex behaviors, including spontaneous alignment in the presence of chemical gradients and altering rheological properties of the fluid,” stated the researchers. “Translating these complex behaviors to artificial systems is especially attractive for applications in fluid transport, small-scale mixing, and targeted cargo delivery but is hard due to intrinsic nanofabrication limitations.”
Many of the simplest constructs so far have proven to be inferior in terms of swimming and other behavior—making it obvious that greater strides must be made before such particles become a functional reality for scientists. In this project, the researchers created swimming tori manipulated by a magnetic field. These constructs were able to transport the following:
- Other artificial swimmers
- Bimetallic nanorods
- Passive colloidal particles
They created a hydrodynamic and propulsion mechanism independent model “to account for the new emergent phenomena in swimming microtori near boundaries,” along with pinpointing the elements required for swimming—self-induced slip velocities across the surface and electrostatic potentials. This left the team open to experimenting further with alternative mechanisms, with findings that are relevant to other biocompatible systems like mounted enzymes, and light.
Using two-photon lithography, the researchers 3D printed programmable structures, with tori that were both chemically powered, and imbued with nanoscale features. The research team explains in their paper that tori were either glazed or Janus, or patchy.
“In the presence of hydrogen peroxide, the tori instantaneously begin to hover above the surface because of the self-electrophoretic propulsion. Due to the charge instability, i.e. moving surface charges arising from self-electrophoresis, the tori spontaneously break symmetry and tilt to a stable angle. The tori then glide across the surface; eventually organizing into dynamic clusters that swim in three dimensions,” explained the authors.
“The addition of more complex external fields and chemical gradients can be used to indirectly and directly guide the autonomous swimmers. The tori could then be directed to deliver living cargo, such as cells, to specific sites for cell therapy; or collectively organize the tori to direct their flow for cellular transport and sorting.”
3D printing is connected with a fascinating range of scientific projects, to include delivery systems on the nano- and micro-scale—whether in using hydrophilic matrices, micro reservoir devices, or even spermbots. What do you think of this news? Let us know your thoughts; join the discussion of this and other 3D printing topics at 3DPrintBoard.com.[Source / Images: ‘Shape-programmed 3D printed swimming microtori for the transport of passive and active agents’]
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