Organovo Presents Promising Preclinical Data on 3D Bioprinted Human Liver Tissue, Announces Distributor Agreement with Japanese Supplier Cosmo Bio

Share this Article

swm_organovo-featCalifornia-based biology company Organovo, dedicated to delivering scientific and medical breakthroughs with its innovative and celebrated 3D bioprinting technology, is presenting the first preclinical data on its 3D bioprinted human liver tissue, and the results are promising. The data, being presented at the TERMIS-Americas Meeting in San Diego, shows survival and sustained functionality of the tissue when implanted into animal models. This comes just months after the company announced its plans to develop its 3D bioprinted human liver for transplant. The company, which reported a 209% revenue growth for Q1 FY2016 over Q1 FY2015 thanks to its bioprinted liver tissue, also partnered with Uniquest last year to work on patenting and bioprinting kidney tissue. So it’s exciting to see what will happen next, as ambitious Organovo is bringing us ever closer to the real possibility of functional 3D printed human tissue restoration that appears almost indistinguishable from natural tissue.

organovo-home-image (1)Organovo implanted 3D bioprinted human liver tissue patches, composed of human hepatocytes and select non-parenchymal cells, onto the livers of NOD/SCID (immunodeficient) mice. Scientists and researchers were able to tell that the tissue patches were functioning in the mice through the detection of proteins like human albumin and fibrinogen, as well as protease inhibitor alpha-1-anti-trypsin, in their circulating blood in as early as seven days post-implantation. Microscopic examination and evaluation of the implanted tissue showed that the bioprinted cellular organization was retained for at least 28 days, along with staining for enzymes that are associated with inborn metabolism errors, such as Ornithine Transcarbamylase (OTC) deficiency, which can cause ammonia to accumulate in the blood.

Eric Michael David, M.D., J.D., chief strategy officer, and executive vice president of Organovo’s preclinical development, said, “With a critical shortage of donor organs and few alternatives to transplantation, Organovo is using its 3D bioprinting technology to develop novel therapeutic tissues for direct surgical implantation. Our preclinical data show rapid vascularization and tissue engraftment, and evidence of function and durability of our 3D bioprinted human liver tissue over several weeks. Most importantly, we see evidence of stable production of key human liver proteins in the animal bloodstream, and tissue staining for key human metabolic enzymes. The presence of these enzymes provides an important first step in demonstrating the capability of this tissue to treat inborn errors of metabolism, a key indication we are targeting.”

The NovoGen Bioprinter fabricating tissue.

The NovoGen Bioprinter fabricating tissue.

The bioprinted tissues were able to stay intact on the animal livers, and the mice tolerated them well. Both of these facts support continuing preclinical development of Organovo’s 3D bioprinted liver tissue for therapeutic use, and Organovo plans to submit an Investigational New Drug application to the US Food and Drug Administration (FDA) for its therapeutic liver tissue in a few years. The application will focus on acute-on-chronic liver failure and pediatric inborn errors of metabolism, both of which could could be helped using the therapeutic benefits from a bioprinted liver patch. Organovo will first pursue other opportunities, like breakthrough therapy designation and clinical development outside of the United States, to help accelerate the time to market for its valuable 3D bioprinted tissue. This makes sense, as the total market opportunity for the initial technology in the US exceeds $3 billion.

cosmobio-logoSpeaking of development outside of the US, Organovo also recently announced an exclusive distributor agreement with Cosmo Bio Co., Ltd. for its NovoView Preclinical Services in Japan. Headquartered in Tokyo, Cosmo Bio is one of the country’s largest and most established suppliers in the life science industry, with a vast network of over 200 contracted dealers in Japan.

Organovo’s general manager, Paul Gallant, said, “We’re committed to expanding our customer footprint in Asia, as four of the world’s Top 25 global pharmaceutical companies are located in Japan. Cosmo Bio is an ideal distribution partner for our liver and kidney tissue testing services because of their deep network, strong customer relationships and excellent track record selling the products and services of leading research tool companies.”

This is different than Organovo’s research agreement with Merck Sharp & Dohme Corp. Cosmo Bio was established to sell and distribute biological reagents and services for the purposes of medical research. In order to get important, direct access to customers and other support projects in Japan’s biopharmaceutical industry, Organovo will be working with their Drug Discovery Services team. Discuss in the Organovo forum at 3DPB.com.

Share this Article


Recent News

Blueprint Launches Technology Enablement Program—Brings Greater Knowledge to 3D Printing Users

MIT: A New Fiber Ink With Electronics Embedded Inside



Categories

3D Design

3D Printed Art

3D Printed Food

3D Printed Guns


You May Also Like

TU Delft Researchers Create Soft Robotics that Respond to Color-Based Sensors

As 3D printing and robotics continue to collide and complement each other, new machines are being created. In soft robotics, we’re seeing the emergence of a class of machines that...

MIT: Automated System Designs and 3D Prints Optimized Actuators and Displays to Spec

Actuators are complex devices that mechanically control robotic systems in response to electrical signals received. Depending on the specific application they’re used for, today’s robotic actuators have to be optimized...

Using Casting, Graphene, and SLM 3D Printing to Create Bioinspired Cilia Sensors

  What Mother Nature has already created, we humans are bound to try and recreate; case in point: biological sensors. Thanks to good old biomimicry, researchers have made their own...

Nanyang Technological University: Inkjet Printing of ZnO Micro-Sized Thin Films

In ‘Inkjet-printed ZnO thin film semiconductor for additive manufacturing of electronic devices,’ thesis student Van Thai Tran, from Nanyang Technological University, delves into the realm of fabricating products with conductive...


Shop

View our broad assortment of in house and third party products.


Print Services

Subscribe To Our Newsletter

Subscribe To Our Newsletter

Join our mailing list to receive the latest news and updates from our 3DPrint.com.

You have Successfully Subscribed!