University of Akron: Thesis Student 3D Prints PPF Structures for Bone Regeneration Applications
In ‘Synthesis, characterization and 3D printing of linear and star-shaped poly(propylene fumarate) for medical applications,’ Yuanyuan Luo offers a PhD dissertation for The University of Akron on the subject of additive manufacturing and new polymer synthetics for use in the medical realm.
As materials science continues to expand, researchers are drawn to exploring the uses of 3D printing for complex geometries in regenerative medicine like cranial facial bone defect repair. Features like the following are required:
- Suitable molecular weight
- Molecular mass distribution
- Proper glass transition temperature properties
“The failing to reliably and reproducibly produce a material may cause final device failure in tests like mechanical, biocompatible and/or pre-clinical animal studies, let alone to pass FDA regulations,” explains Luo, focusing on Poly(propylene fumarate) (PPF)—a non-toxic polyester material that is also amorphous, degradable, and can be cross-linked.
Luo explains how PPF can be synthesized for 3D printing and used in high-resolution applications for bone regeneration. The star-shaped PPF was also capable of achieving higher molecular mass and offering ‘significant improvements’ in comparison to other methods.
The author continues to discuss the challenges historically encountered, however, in the use of 3D printing to create implants for bone regeneration, along with benefits such as better reproducibility in scaffold fabrication, improved accuracy, and better mechanical properties.
Some ‘resorbable polymers’ have been used thus far in regenerative applications, listed in the table below.
“Although these resorbable polyesters have been clinically used in several degradable medical devices, they are not suitable for bone tissue regeneration due to some of their inherent physical and chemical properties,” explains Luo, emphasizing the need for new resorbable polymers.
PPF is considered suitable due to the many beneficial features it offers, along with biocompatibility and tunability. It can also be crosslinked with itself and reactive diluents like diethyl fumarate, a critical quality in bone tissue engineering since the materials must be similar in properties to the tissue being replaced. PPF materials can also be used effectively as drug delivery systems.
PPF has also been used in several pre-clinical studies, but the author reports some ‘significant barriers,’ due to issues with step growth polymerization—one of the methods that can be used, along with ring opening copolymerization (ROCOP). With the use of PPF-based resins, the researchers were able to 3D print at higher molecular mass level, achieving more ‘diverse’ mechanical properties.
“Such reproducible synthetic methods and resin viscosity tuning techniques not only paved the road to further identify the potential of using 3D printed PPF scaffolds in regenerative medicine field, but also can be adapted for the developing other related biomaterials,” concluded the researchers.
3D printing and bone regeneration are a hot topic these days, with researchers experimenting with titanium in additive manufacturing, exploring with electrospinning and 3D printed scaffolds, and studying issues like annealing. What do you think of this news? Let us know your thoughts! Join the discussion of this and other 3D printing topics at 3DPrintBoard.com.[Source / Images: ‘Synthesis, characterization and 3D printing of linear and star-shaped poly(propylene fumarate) for medical applications’]
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