As innovation in materials grows into a vast science—especially within the 3D and 4D printing realms, medical patients of today and the future can look forward to improved, patient-specific care. Researchers from Queen’s University Belfast study the implications and potential with enhanced PLA in ‘Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications.’
Lignin (LIG) is a natural biopolymer containing antioxidants. To see if these properties would carry through after serving as a coating for PLA pellets and then being 3D printed, the researchers placed the material into an extruder at 200 ◦C. Their suppositions proved correct as not only did the filament work successfully, but it passed on antioxidants.
“A wound healing model compound, curcumin (CUR), was applied in the surface of the mesh and its diffusion was studied,” stated the researchers. “It was observed that the dimensions of the meshes affected the permeation rate of CUR. Accordingly, the design of the mesh could be modified according to the patient’s needs.”
The use of PLA is popular for many reasons, beginning with its percieved biodegradability factor, and lack of toxicity. Suitable for FFF 3D printing, the vegetable-based filament can be combined with other molecules and has shown increasing merit for medical applications, especially in accelerating healing of wounds. This type of study has not been expansive previously, however, harnessing the power of lignin’s antioxidant and antimicrobial properties. Lignin is of interest as an extremely abundant polymer that the researchers contend is highly unexploited. It is an affordable material to acquire and use, and useful in a variety of other applications currently.
The researchers used different types of mesh with a 2 percent combination of LIG in the PLA, along with curcumin (CUR) applied in the material and diffused. They discovered better effectiveness with the meshes when using a size of 1mm. The research team also found that the release rate was delayed if they used both the mesh and a soluble PVA film, printed with the mesh on an FDM 3D printer with a dual extruder. The PVA film may also function in dual capacity as it not only delays the release of CUR, but also keeps the wound moist.
“A potential scenario for this material is as a wound dressing material due to the antioxidant activity of the composite material that can contribute to wound closure. Due to the low price of 3D printing equipment and its versatility, these materials can be used in hospitals to print wound dressings for patients on demand,” concluded the researchers.
“Due to the enhanced cell proliferation on antioxidant materials [16], these materials can be used for tissue culture applications or even for regenerative medicine. Due to the versatility of FFF, complex geometries can be prepared such as scaffolds. However, before this type of materials can be implanted into humans, the safety of lignin-based materials should be evaluated. It has been reported before that LIG-based materials are biocompatible [45] but more studies should be performed.”
3D printing continues to make substantial impacts in the medical arena, innovating for better ways to heal wounds, along with improving drug-delivery systems, and assisting in tissue regeneration. What do you think of this news? Let us know your thoughts! Join the discussion of this and other 3D printing topics at 3DPrintBoard.com.
[Source / Images: Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications]Subscribe to Our Email Newsletter
Stay up-to-date on all the latest news from the 3D printing industry and receive information and offers from third party vendors.
You May Also Like
Wisconsin’s Evology Adds Digital Sheet Forming to Service Roster
Evology, a service bureau based in Wisconsin and specializing in serving strategic sectors like aerospace and defense, has added digital sheet forming (DSF) to its repertoire of manufacturing capabilities. Evology...
Boring Company Alum Score $9M for Advanced Composites Manufacturing
Layup Parts, a Huntington Beach, CA-based startup specializing in on-demand manufacturing of parts made from composites, has received $9 million in its latest financing round. Founders Fund, the VC firm...
Industrial Giant Ingersoll Rand Leads $19M Round Backing Inkbit’s AI-Driven 3D Printing
Inkbit, the Massachusetts-based original equipment manufacturer (OEM) of multi-material, AI-integrated 3D printers, has closed a $19 million financing round. Ingersoll Rand, a US giant in the industrial equipment sector, led...
3YOURMIND & Nigerian Oilfield Services Firm RusselSmith Team Up on 3D Printed Part Inventory
3YOURMIND, the German and U.S. software services provider specializing in digital inventory platforms for additive manufacturing (AM), has partnered with Nigerian oilfield services firm RusselSmith to digitize spare part files...