EPlus3D

University of Pittsburgh Research Teams Create 3D Printed, Metal, Biodegradable Bone Scaffolds

Formnext Germany

Share this Article

The 3D printer may soon be one of the most invaluable machines in the surgical theater. Researchers at the University of Pittsburgh McGowan Institute for Regenerative Medicine  have collaborated to create a new technique for repairing damaged bone and tissue. Using a 3D printer they produced a kind of microscopic biodegradable scaffold of an iron and manganese alloy to foster new bone and tissue growth.

An ingot of the iron-manganese alloy.

An ingot of the iron-manganese alloy.

Remarkably, a 3D printer is being used to generate print using an alloy, which is customized to remain openly porous, allowing new cell growth to occur within the framework of the scaffold. In addition to printing the iron-manganese scaffold structure, a 3D printer is also used to print scaffolds which promote the formation of cells called pre-osteoblasts. Pre-osteoblasts are the precursors to osteoblasts, the single-nucleus cells that synthesize bone; that is, they are the basis for bone growth and development.

The research team, Prashant Kumta, Howard Kuhn, and Patrick Cantini concluded that the iron-manganese alloy scaffold is superior to that of an exclusively iron one as it approximates the “tensile mechanical properties” of natural bone. When the scaffold is applied to the bone in need of repair, the pre-osteoblasts infiltrate the pores in the structure and work within the bone, thus comprising this groundbreaking reconstruction process. As the healing proceeds, the scaffold is designed to degrade and the iron and manganese contribute to the rebuilding, supplying critical minerals.

CAT scans (computer-aided tomography) determine where the scaffold is best applied to the damaged bone or tissue. Using computer imaging, specialists then design the scaffold, a process which is far superior to previous methods such as bone grafting. With bone grafting, there is always a risk of disease transmission but this technique eliminates that possibility and instead promotes the growth of natural tissue as the body heals without risking infection or otherwise compromising the reconstruction process based on additive manufacturing. Further, the iron-manganese alloy scaffold is far superior to one that would be produced from plastic or ceramic, particularly as it degrades as the repair process is transpiring, rather than remaining in place after it is no longer needed.

The University of Pittsburgh’s dual-department team was recognized for their innovative project, “Additive Manufacturing of Biomedical Devices from Bioresorbale Metallic Alloys for Medical Applications,” by America Makes, the National Additive Manufacturing Innovation Institute. In layman’s terms, of course, “additive manufacturing” is 3D printing. In an effort to foster further growth of the 3D printing industry and to ensure that the United States is a global leader in the industry, Youngstown, Ohio-based America Makes encourages collaboration between non-profit organizations, business, academia, and government agencies. This University of Pittsburgh team is partnering for the next year-and-a-half with the corporations, ExOne, Hoeganaes, and Magnesium Elektron with $590,000 in funding.  Discuss this story in the Metal Implant forum thread on 3DPB.com.
bones

Share this Article


Recent News

3D Printing Webinar and Event Roundup: October 1, 2023

3D Printing News Briefs, September 30, 2023: Drone Customization, 3D Printed Bandage, & More



Categories

3D Design

3D Printed Art

3D Printed Food

3D Printed Guns


You May Also Like

Defense Official: Pentagon is “Turning a Corner” in 3D Printing

Just after the Pentagon made announcements of $270 million in new spending for US advanced manufacturing efforts in a span of less than ten days, Keith DeVries, the deputy director...

Custom 3D Printed Radiotherapy Solutions to Be Distributed in the US & Canada

3D Systems, the Rock Hill, South Carolina-based additive manufacturing (AM) pioneer, announced that the company has partnered with Klarity, a leading supplier of radiotherapy solutions, to distribute 3D Systems’ VSP...

3D Printed Clay Made Stronger with Fungus in New Research

The Institute of Architecture and Media at Graz University of Technology has recently released an intriguing paper titled “MyCera: Application of Mycelial Growth Within Digitally Manufactured Clay Structures.” The research...

3D Printing News Unpeeled: BLT, M Holland & Tecnológico de Monterrey

BLT has announced its half year results for 2023 with $2.44 million in profit for the first half year up from a $5.34 million loss last year for the same period....