Exone end to end binder jetting service

3D Printed Bioplotting May Offer Comfort to Diabetes Patients

INTAMSYS industrial 3d printing

Share this Article

bioplotting scaffoldType 1 diabetes is a malady usually diagnosed in children and young adults, once known as juvenile diabetes. Only five percent of diabetes sufferers have this form of the disease; in Type 1 diabetes, the body fails to produce insulin, a hormone the body uses to convert sugar, starches, and other food into energy.

With a combination of insulin therapy and various other treatments, even the youngest children can learn to manage their condition and live long, relatively healthy lives.

One of the ways patients can compensate for their lack of insulin is via an as-yet experimental procedure. Called pancreatic islet transplantation, it’s a process in which clusters of cells are transplanted from the pancreas of a healthy donor.

There is a major side effect of this treatment. It requires that a patient undergo ongoing doses of immunosuppressant drugs to prevent the patient’s body attacking the foreign, transplanted cells.

Now a new approach offers relief from that issue by using a 3D printed scaffold as a delivery technique to manage the condition.

In Type 1 diabetes, a patient’s system can display low levels of glucose in the blood. The condition is known as hypoglycemia, and its effects are both unpleasant and potentially lethal.

Now researchers at the University of Twente in the Netherlands have built scaffolds  they say will improve the success rate of pancreatic islet transplantation by embedding the islets within a mixture of alginate and gelatin.

BF513482_suppdata_figure1They call the process bioplotting, and it results in a porous, 3D printed structure which allows for an optimum exchange of glucose and insulin.

In fact, lab results have shown these 3D printed islets and scaffolds are every bit as capable of performing the role as the islet cells they replace and that they provide the necessary protection against the immune system response of the body.

Dr. Aart van Apeldoorn, a co-author of the research, says this “immunoprotective scaffold” may be developed by using a non-degradable hydrogel. The hydrogel includes a proper mesh size which can block antibodies and immune system-specific cells while the mesh remains large enough to allow for insulin diffusion.

“If we are to improve the success of this treatment for Type 1 diabetes, we need to create an implant in which islets are embedded, or encapsulated, from a material that allows for very efficient oxygen and nutrient supply, and quick exchange of glucose and insulin, while keeping the host cells out,” says van Apeldoorn.

According to van Apeldoorn, these “macroporous scaffolds” ensured that the islet cells held within them wouldn’t migrate uncontrollably throughout the rest of the body once transplanted into the donor site.

Results of the research were published in the journal Biofabrication.

What do you think of this biofabricated treatment, which may one day help Type 1 diabetics avoid ongoing immunosuppresant treatments? Let us know in the 3D Printed Bioplotting forum thread on 3DPB.com.

 

BF513482_suppdata_figure2

 

 

Share this Article


Recent News

$51M to Ramp up 6K’s Production of Batteries and 3D Printing Metals

Secret Audit Reveals US Military’s 3D Printing Tech Vulnerable to Cyberattacks



Categories

3D Design

3D Printed Art

3D Printed Food

3D Printed Guns


You May Also Like

3D Printing News Briefs, September 9, 2021: Events, Materials, & More

In today’s 3D Printing News Briefs, the first Formnext + PM South China finally opens this week. In materials news, a biomedical company introduced what it calls the first purified...

Featured

US Navy Issues $20M to Stratasys to Purchase Large-Format 3D Printers

The U.S. Navy has been steadily increasing its investment into practical 3D printer usage, as opposed to research. The latest comes in the form of a whopping $20 million contract...

3D Printing Webinar and Event Roundup: August 22, 2021

From food 3D printing and GE Additive’s Arcam EBM Spectra L 3D printer to 3D printing and CAD in a post-pandemic world and topology optimization, we’ve got a busy week...

Featured

The Largest 3D Printed Structure in North America: a Military Barracks in Texas

ICON’s latest 3D printed training barracks structure in Texas signals another positive step for the additive construction industry. Described by the company as the largest 3D printed structure in North...


Shop

View our broad assortment of in house and third party products.