AM Investment Strategies
AMS Spring 2023

Moscow Researchers 3D Print Bone Substitutes With Ceramic Powder 3D Printer

Formnext

Share this Article

The collaborative effort of researchers from a variety of institutes in Moscow has resulted in a paper published in the most recent issue of Frontiers in Bioengineering and Biotechnology. The researchers hail from the A.A. Baikov Institute of Metallurgy and Materials Science of Russian Academy of Sciences; Institute of Laser and Information Technologies, Russian Academy of Sciences; Human Stem Cells Institute; and Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center.

It has become commonly accepted that 3D printing bone is a highly effective method for the creation of bone replacement as well as for scaffolding of both newly generated tissue and bone. In this paper, titled “3D printing of octacalcium phosphate bone substitutes,” the researchers proposed a comparatively simple way in which octacalcium phosphates could be printed in complex shapes through a combination of inkjet printing and post-print finishing.

“Biocompatible synthetic grafts and/or tissue engineering constructions prevail over conventional approaches…However, complex structure and properties of natural bone limit the spectrum of synthetic materials and fabrication techniques that could be used as custom-designed implants or scaffolds for bone defects replacement or guided bone regeneration. Currently, this problem might be solved via a 3D printing technique,” the researchers wrote.

Screen Shot 2015-05-25 at 9.53.53 AM3D printing is uniquely prepared to handle exactly such geometric complexities and the abilities for repeated and easy customization have made it the method of choice for an increasing number of medical applications. The development of synthetic calcium phosphates, the material for the human-made creation of replacement bone, has allowed for the creation of substitute structures in areas where there is a significant amount of bone missing or damaged.

Creating a replacement bone is more complex than simply making a hard structure that can fill in for missing or damaged bone. The replacement must be compatible with the human body and ideally trigger the body’s capacity to regenerate bone after it has been transplanted. The development of a material known as octacalcium phosphate (OCP), which is comprised of microporous ceramic granules, is a very effective and promising material for these requirements. For this reason, the researchers chose to utilize this material for their investigation.

There are two primary techniques utilized in 3D printing ceramics. The first involves a mixing of the material cocktail that is chemically solidified and then subject to processing at high temperatures. The second involves inverse matrix printing and the burning out of the negative. The researchers determined that the first method was the most appropriate as the burning out of the support material required by the second process increased the risk of contamination.

Custom designed 3D printer

Custom designed 3D printer

The team utilized a custom designed 3D printer that built up layers of the ceramic material on a small bed (60 x 60 x 60 mm). The diminutive size of the bed meant that researchers could perform fast and inexpensive studies of a variety of processes and material combinations.

“3D printing techniques based on cement powders is an effective and inexpensive method for individual and complex bone substitute’s fabrication since there is neither support materials burning out nor organic solvent required,” the team concluded.

The results of the study were not entirely positive, however. Defects in the implants revealed themselves after six months and further study is needed in order to better understand the origin of such defects and how to address them.

“The results of our study demonstrate that a combination of 3D inkjet printing with post-treatment methodology is a promising approach to overcome current limitations in effective and fast fabrication of individual constructions for guided bone regeneration,” they wrote.

Are you familiar with similar developments? Discuss in the 3D Printed Bone Research forum thread over at 3DPB.com.

Screen Shot 2015-05-25 at 9.52.19 AM

 

Share this Article


Recent News

3D Printing Webinar and Event Roundup: October 2, 2022

3D Printing News Briefs, October 1st, 2022: Flight-Ready Parts, Rapid Prototyping, & More



Categories

3D Design

3D Printed Art

3D Printed Food

3D Printed Guns


You May Also Like

Featured

Formlabs & Hasbro Commercially Launch Selfie Series of 3D Printed Action Figures

Earlier this summer, Formlabs announced that it was teaming up with global play and entertainment company Hasbro (NASDAQ: HAS) to launch a new series of action figures featuring the faces of...

3D Printing News Briefs, September 29, 2022: Crowdfunding a 3D Printed House & More

We’re kicking things off with business in today’s 3D Printing News Briefs, as a Dallas construction startup is looking to raise $2 million to 3D print homes. LÖMI joined the...

Quickparts Expands Manufacturing Capabilities with Xcentric Mold & Engineering Acquisition

The 3D printing industry is continuing a trend of consolidation amid broader economic turbulence. The latest news on that front is the acquisition of Xcentric Mold & Engineering by Quickparts,...

Zortrax Launches End-to-End Industrial mSLA 3D Printing Platform

Zortrax, the leading Polish original equipment manufacturer (OEM) of additive manufacturing (AM) solutions, announced the launch of the company’s latest platform, the Inkspire 2 UV LCD photopolymer printer. Additionally, Zortrax...