Bioprinting at University of Pennsylvania: Impacts on Conductivity in Granular Hydrogels
To reach the goal of 3D printing human organs, bioprinting must continue to evolve. Researchers are not only aware of this, but as they are part of the process in seeking to make huge impacts in the medical realm, they continue to refine bioprinting in new studies like the one outlined in the recently published ‘Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support.’
- Hydrogel microparticles are created with water-in-oil emulsions.
- Microgels are customized during an in situ reduction process.
- Microgels are ‘jammed’ into extrusion from a syringe.
Conductivity of the hydrogels was easily modified in the new concept created by the authors, based on the assembly of hyaluronic acid microparticles into solids containing metal-phenolic networks. Reduction is based on gallol moieties, common polyphenols with a natural base.
“The gallol moiety has benzene‐1,2,3‐triols, capable of being oxidized to form galloquinones and to donate two electrons per one molecule,” stated the researchers. “When coupled with this oxidation of gallol, metal ions (e.g., M+) are reduced to generate metal nanoparticles (e.g., M0). Furthermore, gallols may act as chelators to form coordinated networks with metal nanoparticles.
“Further, the intrinsic injectability of granular hydrogels allows fabrication of 3D printed electroactive patterns (e.g., wearable and flexible electronic devices) and electrophysiological support for biological tissues (e.g., myocardium, skeletal muscles).”
The in situ technique offers even greater potential than embedding, refining both conductivity and mechanical properties. The electrical conductivity of the hydrogels was explored further as the authors expected further enhancements due to a large surface area conducive to ‘continuous electric flow.’
Hydrogel structures and their variances impacted conductivity; for instance, within the microgels lacking AgNPs altogether, limited conductivity existed. With the addition of AgNPs, however, conductivity was improved. Size and morphology were noted to make a difference in conductivity too but thought to be dependent on ‘magnitude.’
“Since the metal–phenolic coordination network involved in microgel interactions is dynamic and reversible, applications should consider the potential for dissociation of the microgels and whether further secondary crosslinking is needed for hydrogel stability. For instance, conductivity decreased from 0.05 to 0.01 S cm−1 when incubated for 5 days at body temperature due to a gradual loss of the physicochemical network between microgels,” concluded the researchers.
“The conductive granular hydrogels allowed 3D printable extrusion, fabricating free‐standable constructs on the polymeric film with conductivity as a function of the volumetric ratio of the microgels with/without metal nanoparticles. In addition, the conductive microgels restored electrical conduction by bridging two separated muscle tissues. Our findings present a new technique in the design of soft conductive materials that are also injectable, a promising approach for enhancing electrical conductivity for numerous biomedical applications.”
Bioprinting has led to the use of many different hydrogels—and a range of different research projects around the globe—from shape-shifting hydrogels to those that are created from chitosan or alginate. What do you think of this news? Let us know your thoughts; join the discussion of this and other 3D printing topics at 3DPrintBoard.com.[Source / Images: ‘Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support’]
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