AMS Spring 2023

Potentially Revolutionary Spina Bifida Treatment That Uses 3D Printing Wins Major STW Grant

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3dp_spinabifida_diagramResearchers from Leiden University and Erasmus medical centers recently received the prestigious €50,000 Open Mind grant from science and tech foundation STW to continue developing their early term surgical procedure to prevent spina bifida. Professor Dick Oepkes from LUMC and Alex Eggink of Erasmus MC developed a surgical solution to the common birth defect that will correct the gaps on the backs of developing fetuses. The minimally invasive procedure is performed early in pregnancy and uses a revolutionary in utero 3D printing technique to prevent the fetus’ spine and nerves from being damaged by its mother’s amniotic fluid.

Spina bifida is a birth defect where a the backbone and membranes around the spinal cord do not completely close around them. The condition affects between 1,500 and 2,000 of the 4 million babies born in the US every year, and there is currently an estimated 166,000 people living with spina bifida. While spina bifida can be detected early in pregnancy, the current options for correcting it are limited. Parents can choose to either end the pregnancy early, or choose a dangerous surgery that can be very stressful and difficult on both the mother and fetus.

The early surgical procedure involves opening the mother’s womb and operating on the fetus, but by the time that option is available several toxic substances from the amniotic fluid have already caused irreversible damage to the fetus’ nerves. In addition to mobility issues, other complications can include serious latex allergies, a dangerous buildup of cerebrospinal fluid in the head and ongoing incontinence issues. Spina bifida can also cause problems with cognitive control, developmental and learning difficulties and severe ADHD.3dp_spinabifida_fetalsurgery

“After birth the surgeon closes the defect on the back to cover the nerves. However, this is not a cure. The nerves are already damaged before birth; these children are wheelchair-bound for the rest of their life,” explained Oepkes during his pitch to receive the Open Mind grant.

The 3D printing technique that Oepkes and his team of fellow researchers developed, one of several similar procedures being developed all over the world, could be used extremely early in the pregnancy. Not only is it far easier and considerably safer, but it would potentially offer much better results and could prevent most cases of spina bifida from developing far enough along to cause many of the difficulties faced by those living with the condition today. The 3D printed seal is completely flexible and will grow with the fetus as it develops in it’s mother’s womb. If Oepkes research program progresses as currently planned the treatment could be available within the next few years.3dp_spinabifida_3dp_demo

Here is some video of Oepkes discussing this new surgical procedure:

STW is a large Dutch technology foundation that has a €101 million yearly operating budget funded by the Netherlands Organization for Scientific Research, the Ministry of Education, Culture and Science and the Ministry for Economic Affairs. They also receive significant funding from private donors and business financing partners. Their Open Mind grant was designed to challenge scientists to think of out of the box solutions, to develop original and risky lines of research in the tech and medical fields that can create social impact.  Discuss this story in the Spina Bifida / 3D Printing forum thread on 3DPB.com.

 

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