Read Before You Vape: 3D Printed Screening Device Shows That E-Cigarettes Are Just as Bad as Tobacco Cigarettes
In 2004, battery-powered electronic cigarettes (e-cigarettes) hit the commercial market – the devices heat up liquid and turn it into an aerosol vapor, or e-liquid, that can be inhaled. The contents typically consist of nlycerine, propylene glycol, flavoring (like mint or menthol), and varying (or nonexistent) levels of nicotine; we’ve even seen some 3D printed vaporizers for e-cigarettes. People who are trying to kick the habit can choose to take up vaping as a less toxic alternative, as the amount of nicotine in e-cigarettes is not nearly as harmful as it is in tobacco cigarettes…or so we thought. A recently published study by chemists at the University of Connecticut (UConn) has new evidence that e-cigarettes could be just as bad for us as real cigarettes.
UConn postdoctoral chemistry researcher and lead author of the study Karteek Kadimisetty said, “From the results of our study, we can conclude that e-cigarettes have as much potential to cause DNA damage as unfiltered regular cigarettes.”
The UConn team used a low-cost, 3D printed testing device to determine that e-cigarettes with nicotine-based liquid can cause just as much DNA damage as unfiltered tobacco cigarettes, and also that the vapor from non-nicotine cigarettes is as harmful to our DNA as filtered cigarettes, perhaps because of all the chemical additives in e-cigarette vapors. The National Institute of Environmental Health Sciences, from the National Institutes for Health, provided funding for the study.
Last year, the FDA tightened e-cigarette regulations amidst growing concern about their possible health impacts, including if they act as a gateway for future tobacco smokers. Scientists at UConn wanted to test out their newly developed electro-optical screening device and see if the chemicals in e-cigarettes were harmful to human DNA. The team believes that its small 3D printed screening device is the first of its kind that quickly detects DNA damage, or genotoxicity, in environmental samples in the field. DNA damage that causes cellular mutations can lead to a cancer diagnosis, so the work the UConn team is doing is pretty important.“Some people use e-cigarettes heavily because they think there is no harm. We wanted to see exactly what might be happening to DNA, and we had the resources in our lab to do that,” said Kadimisetty.

Small 3D printed array created by UConn chemists quickly detects potential DNA damage from toxic chemicals. [Image: Karteek Kadimisetty and ACS Sensors journal]
The UConn array offers an extremely fast-acting initial genotoxicity screening tool, and the essential carbon chip is disposable, and, thanks to recent advances in 3D printing technology, costs only one dollar to fabricate.
UConn chemistry professor James Rusling, the senior researcher on the study, said, “What we developed is very cheap to make, efficient, and can be used by almost anyone.”

Postdoctoral researcher Karteek Kadimisetty holds the 3-D printed sample chamber of his genetic toxicity testing device. [Image: Peter Morenus/UConn]

UConn chemists tested e-cigarettes and tobacco cigarettes for potential DNA damage caused by a known carcinogen (NNK) at different inhalation rates. This chart shows DNA damage from nicotine e-cigarettes (EC) was approximately equivalent to damage caused by smoking unfiltered cigarettes (nf-TC). [Image: Karteek Kadimisetty and ACS Sensors Journal]
Kadimisetty was surprised by the results, which showed that the potential DNA damage from e-cigarettes increased with the number of puffs.
“I never expected the DNA damage from e-cigarettes to be equal to tobacco cigarettes. I was shocked the first time I saw the result, so I ran the controls again. I even diluted the samples,” Kadimisetty said. “But the trend was still there – something in the e-cigarettes was definitely causing damage to the DNA.”
The findings of the study, titled “Automated 3-D Printed Arrays to Evaluate Genotoxic Chemistry: E-Cigarettes and Water Samples,” were published in the ACS Sensors journal; co-authors include Kadimisetty, Rusling, and Spundana Malla, a scientist at Alliance Pharma and a former UConn PhD student. Kadimisetty explains that how much DNA damage e-cigarettes can cause depends on several factors, like the other additives present in the e-cigarette, how much vapor a person inhales, and whether nicotine or non-nicotine liquid is used.
However, not everyone agrees with UConn’s methodology: the National Health Service (NHS) in the UK, citing its Smokefree campaign, still says that e-cigarettes are better for smokers than tobacco cigarettes, since they don’t produce carbon monoxide or tar.A spokesman for the United Kingdom Vaping Industry Association told Metro, “The public health research in the UK is very clear. Public Health England have found vaping is likely to be 95% less harmful than smoking. The Royal College of Physicians found that vaping did not exceed 5% of the harm from smoking. Earlier this year, Cancer Research UK stated that not only is vaping a safer alternative to tobacco, it’s long term harmful effects appear to be minimal. Though this study certainly warrants further research, the University [of Connecticut] admits that the device they used to measure toxicity is new and not as comprehensive as current techniques of measurement.”
Whether you agree with UConn or the UK Vaping Industry Association, maybe you shouldn’t throw out that nicotine gum just yet. Discuss in the 3D Printed Screening Device forum at 3DPB.com.
[Sources: UConn Today, Metro]
Subscribe to Our Email Newsletter
Stay up-to-date on all the latest news from the 3D printing industry and receive information and offers from third party vendors.
Print Services
You May Also Like
Velo3D Kicks Off New Strategy by Signing $15M Deal with Space Company
Velo3D (OTCMKTS: VLDX) just landed a five-year, $15 million deal with commercial space company Momentus (Nasdaq: MNTS). But this partnership is more than just a revenue boost; instead, it marks...
SWISSto12 to 3D Print Antennas for SES’s Medium Earth Orbit Satellite Constellation
SWISSto12 has made a remarkable journey in satellite manufacturing. The company now produces its own HummingSat, as well as 3D-printed filters, waveguides, and other RF components. Recently, it was selected...
Additive Industries Talks 3D Printing for RF Components, Automotive, & More
Dutch company Additive Industries, which first unveiled its flagship MetalFab industrial 3D printing system in 2015 and officially launched it in 2017, was very busy last year. At Formnext 2023,...
Could Axiom Space and India Disrupt the Global Space Market?
Axiom Space has set its sights on building the next space station to replace the International Space Station (ISS) and is currently in the early stages of developing its first...