“Vessels are made up of different cell types and our new Omega allows for many types of cells to be deposited in 3D,” Dr. Thomas explained. “Biopsied tissue materials can be gathered from a host, with stem cells isolated and multiplied. These cells are cultured and placed in a bioreactor, which provides oxygen and other nutrients to keep them alive. The millions of cells that are produced are then added to our bioink and bioprinted into the correct 3D geometry.”
These new 3D vascular tissue scaffolds are the first commercial tissue product that the company has developed, and commercialization of the bioprinted vessels will begin over the next two years. 3Dynamic Systems has increased its research, and is currently focused on fabricating heterogeneous tissues that can one day be used in the operating room.
Research into 3D bioprinting for future organ transplants is definitely picking up – just last month, Prellis Biologics figured out how to create blood vessels by 3D printing scaffolding that contains microvascular structures, which is necessary to get nutrients and oxygen to cells. At the moment, 3Dynamic Systems only manufactures 20 mm sections of vessels, but could potentially print larger, more complex vessels if this size does well.
The company’s 3D bioprinting research centers around using cells’ natural self-organizing properties to develop functional tissues. The cell-based biogel matures into a tissue a few weeks after the 3D bioprinted vessels are transferred to an incubator. In order to sustain the proteoglycans during the maturation stage, hyaluronic acid is added to the bioink, which is also used by iMakr Med with its bioprinting platform. This is a very important maturation step in the formation of biochemical and structural support material, also called extracellular matrix (ECM).
The company will continue developing its technology, working to harness tissues for pharmaceutical trials, and, in the future, operative repair.
“The next opportunity for our research is in developing organ on a chip technology to test drugs and treatments,” said Dr. Thomas. “So far we have initial data based on our vascular structures. In the future this method may be used to analyze any side-effects of new pharmaceutical products.”
Potentially, the next steps 3Dynamic Systems takes in the development of this process could help change the field of reconstructive medicine, which may even result in the on-demand bioengineering of replacement human tissues for transplantation one day.
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[All images provided by 3Dynamic Systems]